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Platelet Aggregation in Intracranial Stents May Mimic In-Stent Restenosis

Platelet Aggregation in Intracranial Stents May Mimic In-Stent Restenosis SUMMARY: We report the case of an early ISR that was due to platelet aggregation despite correct observance of a standard antiplatelet regimen. Biologic testing showed clopidogrel inefficiency, and ISR disappeared on angiography after a loading dose of clopidogrel. This result suggested that the arterial lumen reduction was due to platelet aggregation rather than in-stent myointimal hyperplasia. This observation emphasizes the importance of verifying the efficacy of clopidogrel before placing a stent. Abbreviations AP anteroposterior CTA CT angiography ISR in-stent restenosis MCA middle cerebral artery TCD transcranial Doppler TIA transient ischemic attack VASP vasodilator-stimulated phosphoprotein. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Neuroradiology American Journal of Neuroradiology

Platelet Aggregation in Intracranial Stents May Mimic In-Stent Restenosis

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References (9)

Publisher
American Journal of Neuroradiology
Copyright
Copyright © 2010 by the American Society of Neuroradiology.
ISSN
0195-6108
eISSN
1936-959X
DOI
10.3174/ajnr.A1778
pmid
19833804
Publisher site
See Article on Publisher Site

Abstract

SUMMARY: We report the case of an early ISR that was due to platelet aggregation despite correct observance of a standard antiplatelet regimen. Biologic testing showed clopidogrel inefficiency, and ISR disappeared on angiography after a loading dose of clopidogrel. This result suggested that the arterial lumen reduction was due to platelet aggregation rather than in-stent myointimal hyperplasia. This observation emphasizes the importance of verifying the efficacy of clopidogrel before placing a stent. Abbreviations AP anteroposterior CTA CT angiography ISR in-stent restenosis MCA middle cerebral artery TCD transcranial Doppler TIA transient ischemic attack VASP vasodilator-stimulated phosphoprotein.

Journal

American Journal of NeuroradiologyAmerican Journal of Neuroradiology

Published: Mar 1, 2010

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