Thermodynamics of Enzyme-Catalyzed Reactions: Part 7—2007 Update
Robert N. Goldberg,
a…
Yadu B. Tewari,
b…
and Talapady N. Bhat
c…
Biochemical Science Division, National Institute of Standards and Technology, Gaithersburg, Maryland 20899
͑Received 13 March 2007; revised manuscript received 14 May 2007; accepted 27 August 2007; published online 25 October 2007
͒
This review serves to update previously published evaluations of equilibrium constants
and enthalpy changes for enzyme-catalyzed reactions. For each reaction, the following
information is given: the reference for the data, the reaction studied, the name of the
enzyme used and its Enzyme Commission number, the method of measurement, the
conditions of measurement ͓temperature, pH, ionic strength, and the buffer͑s͒ and cofac-
tor͑s͒ used͔, the data and their evaluation, and, sometimes, commentary on the data and
on any corrections which have been applied to the data or any calculations for which the
data have been used. The review contains data from 119 references which have been
examined and evaluated. Chemical Abstract Service registry numbers are given for the
substances involved in these various reactions. There is also a cross reference between
the substances and the Enzyme Commission numbers of the enzymes used to catalyze the
reactions in which the substances participate. © 2007 by the U.S. Secretary of Commerce
on behalf of the United States. All rights reserved. ͓DOI: 10.1063/1.2789450͔
Key words: apparent equilibrium constants; enthalpies of reaction; enzyme-catalyzed reactions; evaluated data;
transformed thermodynamic properties
.
CONTENTS
1. Introduction.............................. 1349
2. Acknowledgments......................... 1350
3. References for the Introductory Discussion. . . . . 1350
4. Table of Equilibrium Constants and Enthalpies
of Reaction.............................. 1351
4.1. Enzyme: alcohol dehydrogenase ͑NADP
+
͒
͑EC 1.1.1.2͒.......................... 1351
4.2. Enzyme: homoserine dehydrogenase
͑EC 1.1.1.3͒.......................... 1355
4.3. Enzyme: mannitol-1-phosphate
5-dehydrogenase ͑EC 1.1.1.17͒.......... 1355
4.4. Enzyme:
D
-lactate dehydrogenase
͑EC 1.1.1.28͒......................... 1355
4.5. Enzyme: malate dehydrogenase ͑EC
1.1.1.37͒............................. 1356
4.6. Enzyme: pyridoxine 4-dehydrogenase
͑EC 1.1.1.65͒......................... 1356
4.7. Enzyme: homoisocitrate dehydrogenase
͑EC 1.1.1.87͒......................... 1357
4.8. enzyme: dTDP-4-dehydrorhamnose
reductase ͑EC 1.1.1.133͒................ 1357
4.9. Enzyme: dTDP-4-dehydrorhamnose
reductase ͑EC 1.1.1.133͒................ 1357
4.10. Enzyme: 2-dehydropantoate 2-reductase
͑EC 1.1.1.169͒........................ 1357
4.11. Enzyme: 2,5-diketo-
D
-gluconate reductase
͑EC 1.1.1.274͒........................ 1357
4.12. Enzyme: xanthine oxidase ͑EC 1.1.3.22͒... 1357
4.13. Enzyme: succinate-semialdehyde
reductase ͑EC 1.2.1.a͒.................. 1358
4.14. Enzyme: amine oxidase
͑copper-containing͒͑EC 1.4.3.6͒......... 1358
4.15. Enzyme: dihydrofolate reductase ͑EC
1.5.1.3͒.............................. 1358
4.16. Enzyme: methylenetetrahydrofolate
dehydrogenase ͑NADP
+
͒͑EC 1.5.1.5͒
. . . . . 1358
4.17. Enzyme: saccharopine dehydrogenase
͑NAD
+
,
L
-lysine forming͒͑EC 1.5.1.7͒. . . . 1358
4.18. Enzyme: NAD͑P͒
+
transhydrogenase
͑B-specific͒͑EC 1.6.1.1͒................ 1358
4.19. Enzyme: glutathione reductase ͑NADPH͒
͑EC 1.6.4.2͒.......................... 1359
4.20. Enzyme: superoxide dismutase ͑EC
1.15.1.1͒............................. 1359
4.21. Enzyme: hydrogenase ͑EC 1.18.99.1͒..... 1359
4.22. Enzyme: aspartate carbamoyl-transferase
͑EC 2.1.3.2͒.......................... 1360
4.23. Enzyme: UDP-N-acetylglucosamine
acyltransferase ͑EC 2.3.1.129͒........... 1360
4.24. Enzyme: CO-methylating acetyl-CoA
synthase ͑EC 2.3.1.169͒................ 1360
4.25. Enzyme: purine-nucleoside phosphorylase
͑EC 2.4.2.1͒.......................... 1360
4.26. Enzyme: uridine phosphorylase ͑EC
2.4.2.3͒.............................. 1360
4.27. Enzyme: adenine
phosphoribosyltransferase ͑EC 2.4.2.7͒. . . . 1361
a͒
Electronic mail: robert.goldberg@nist.gov
b͒
Electronic mail: yadu.tewari@nist.gov
c͒
Electronic mail: talapady.bhat@nist.gov
© 2007 by the U.S. Secretary of Commerce on behalf of the United States.
All rights reserved.
0047-2689/2007/36„4…/1347/51/$42.00 J. Phys. Chem. Ref. Data, Vol. 36, No. 4, 2007
1347