Induction of Mammary Cancer with Methylcholanthrene: II. Histological similarity between carcinogen-induced tumors and certain mammary neoplasms occurring spontaneously
AbstractSpontaneous mammary adenocarcinomas in hybrid mice of certain genetic constitution, and presumably without the milk-agent, exhibited a pronounced degree of squamous metaplasia. Thestructure of these tumors was similar to that seenregularly in methylcholanthrene-induced mammary cancers. It is suggested that this histologie type of mammary tumor may be indicative of development independent of the milk-agent. * This investigation has been aided by grants from the Jane Coffin Childs Memorial Fund for Medical Research, the National Cancer Institute, and the Cancer Fund of the Graduate School of the University of Minnesota.