Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Effect of Hyperbaric Oxygen on the Cytotoxicity of Adriamycin and Nitrogen Mustard in Cultured Burkitt's Lymphoma Cells

Effect of Hyperbaric Oxygen on the Cytotoxicity of Adriamycin and Nitrogen Mustard in Cultured... The effects of hyperbaric oxygen (HPO) exposure on the cytotoxicity of Adriamycin (ADM) and nitrogen mustard have been examined in Burkitt's lymphoma cells (P 3 J) in vitro . Exposure of cells to 3 atmospheres of pressure HPO for 2 hr produces inhibition of DNA synthesis and mitosis. Simultaneous exposure to HPO and ADM results in decreased cytotoxicity compared to drug treatment alone. However, exposure to ADM (0.15 µg/ml) 2 to 8 hr before or after HPO produces an increase in drug effect. There is no potentiation of lower ADM concentrations. Cytotoxicity is increased when cells are exposed to HPO during, before, or after exposure to nitrogen mustard (NSC 762) (0.15 and 0.25 µg/ml). Lower nitrogen mustard (NSC 762) concentrations are not potentiated. HPO potentiation of antineoplastic agents appears to depend upon the agent studied, the concentration of the agent, and the scheduling of the drug and HPO exposure. 1 Supported by Institutional Research Grant IN-40N to the University of Michigan from the American Cancer Society. 2 To whom requests for reprints should be addressed. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cancer Research American Association of Cancer Research

Effect of Hyperbaric Oxygen on the Cytotoxicity of Adriamycin and Nitrogen Mustard in Cultured Burkitt's Lymphoma Cells

Effect of Hyperbaric Oxygen on the Cytotoxicity of Adriamycin and Nitrogen Mustard in Cultured Burkitt's Lymphoma Cells

Cancer Research , Volume 39 (2 Part 1 ): 370 – Feb 1, 1979

Abstract

The effects of hyperbaric oxygen (HPO) exposure on the cytotoxicity of Adriamycin (ADM) and nitrogen mustard have been examined in Burkitt's lymphoma cells (P 3 J) in vitro . Exposure of cells to 3 atmospheres of pressure HPO for 2 hr produces inhibition of DNA synthesis and mitosis. Simultaneous exposure to HPO and ADM results in decreased cytotoxicity compared to drug treatment alone. However, exposure to ADM (0.15 µg/ml) 2 to 8 hr before or after HPO produces an increase in drug effect. There is no potentiation of lower ADM concentrations. Cytotoxicity is increased when cells are exposed to HPO during, before, or after exposure to nitrogen mustard (NSC 762) (0.15 and 0.25 µg/ml). Lower nitrogen mustard (NSC 762) concentrations are not potentiated. HPO potentiation of antineoplastic agents appears to depend upon the agent studied, the concentration of the agent, and the scheduling of the drug and HPO exposure. 1 Supported by Institutional Research Grant IN-40N to the University of Michigan from the American Cancer Society. 2 To whom requests for reprints should be addressed.

Loading next page...
 
/lp/american-association-of-cancer-research/effect-of-hyperbaric-oxygen-on-the-cytotoxicity-of-adriamycin-and-Rp8p7anF3f

References

References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.

Publisher
American Association of Cancer Research
Copyright
Copyright © 1979 by the American Association for Cancer Research.
ISSN
0008-5472
Publisher site

Abstract

The effects of hyperbaric oxygen (HPO) exposure on the cytotoxicity of Adriamycin (ADM) and nitrogen mustard have been examined in Burkitt's lymphoma cells (P 3 J) in vitro . Exposure of cells to 3 atmospheres of pressure HPO for 2 hr produces inhibition of DNA synthesis and mitosis. Simultaneous exposure to HPO and ADM results in decreased cytotoxicity compared to drug treatment alone. However, exposure to ADM (0.15 µg/ml) 2 to 8 hr before or after HPO produces an increase in drug effect. There is no potentiation of lower ADM concentrations. Cytotoxicity is increased when cells are exposed to HPO during, before, or after exposure to nitrogen mustard (NSC 762) (0.15 and 0.25 µg/ml). Lower nitrogen mustard (NSC 762) concentrations are not potentiated. HPO potentiation of antineoplastic agents appears to depend upon the agent studied, the concentration of the agent, and the scheduling of the drug and HPO exposure. 1 Supported by Institutional Research Grant IN-40N to the University of Michigan from the American Cancer Society. 2 To whom requests for reprints should be addressed.

Journal

Cancer ResearchAmerican Association of Cancer Research

Published: Feb 1, 1979

There are no references for this article.