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Effect of Aromatic Amines on Isolated Rat-Liver Mitochondria

Effect of Aromatic Amines on Isolated Rat-Liver Mitochondria The effect of some unsubstituted aromatic amines and their o - and p -hydroxylated derivatives on isolated rat-liver mitochondria has been studied. The o -hydroxylated amines inhibited oxygen uptake in the presence of nicotinamide adenine dinucleotide-dependent respiratory substrates. Of the other compounds only 1-amino-4-naphthol inhibited oxygen uptake. The succinate oxidase system was inhibited only by 1-amino-2-naphthol and 1-amino-4-naphthol. The o -hydroxylated compounds impaired the efficiency of oxidative phosphorylation; the effect of 4-amino-3-hydroxybiphenyl was much more evident when -oxoglutarate was used as respiratory substrate. 1-Amino-2-naphthol and 1-amino-4-naphthol completely suppressed phosphate esterification. 1,2-Naphthoquinone and 1,4-naphthoquinone impaired the efficiency of oxidative phosphorylation when supported either by ß-hydroxybutyrate or by succinate. o -Aminophenol, 4-amino-3-hydroxybiphenyl, and 2-amino-1-naphthol stimulated mitochondrial adenosine triphosphatase in the presence of Mg ++ ; the last two compounds inhibited the dinitrophenol-induced adenosine triphosphatase activity. 1-Amino-2-naphthol and 1-amino-4-naphthol inhibited adenosine triphosphatase in the presence of Mg ++ and Mg ++ plus 2,4-dinitrophenol. 1 This work was partially supported by a grant from Consiglio Nazionale Delle Ricerche, Impresa di Enzimologia, Italy. 2 Present address: Chelsea College of Science and Technology, School of Pharmacy, 271/3 King St. Hammersmith, London W.6, England. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cancer Research American Association of Cancer Research

Effect of Aromatic Amines on Isolated Rat-Liver Mitochondria

Cancer Research , Volume 27 (4): 668 – Apr 1, 1967

Effect of Aromatic Amines on Isolated Rat-Liver Mitochondria

Cancer Research , Volume 27 (4): 668 – Apr 1, 1967

Abstract

The effect of some unsubstituted aromatic amines and their o - and p -hydroxylated derivatives on isolated rat-liver mitochondria has been studied. The o -hydroxylated amines inhibited oxygen uptake in the presence of nicotinamide adenine dinucleotide-dependent respiratory substrates. Of the other compounds only 1-amino-4-naphthol inhibited oxygen uptake. The succinate oxidase system was inhibited only by 1-amino-2-naphthol and 1-amino-4-naphthol. The o -hydroxylated compounds impaired the efficiency of oxidative phosphorylation; the effect of 4-amino-3-hydroxybiphenyl was much more evident when -oxoglutarate was used as respiratory substrate. 1-Amino-2-naphthol and 1-amino-4-naphthol completely suppressed phosphate esterification. 1,2-Naphthoquinone and 1,4-naphthoquinone impaired the efficiency of oxidative phosphorylation when supported either by ß-hydroxybutyrate or by succinate. o -Aminophenol, 4-amino-3-hydroxybiphenyl, and 2-amino-1-naphthol stimulated mitochondrial adenosine triphosphatase in the presence of Mg ++ ; the last two compounds inhibited the dinitrophenol-induced adenosine triphosphatase activity. 1-Amino-2-naphthol and 1-amino-4-naphthol inhibited adenosine triphosphatase in the presence of Mg ++ and Mg ++ plus 2,4-dinitrophenol. 1 This work was partially supported by a grant from Consiglio Nazionale Delle Ricerche, Impresa di Enzimologia, Italy. 2 Present address: Chelsea College of Science and Technology, School of Pharmacy, 271/3 King St. Hammersmith, London W.6, England.

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Publisher
American Association of Cancer Research
Copyright
Copyright © 1967 by the American Association for Cancer Research.
ISSN
0008-5472
Publisher site

Abstract

The effect of some unsubstituted aromatic amines and their o - and p -hydroxylated derivatives on isolated rat-liver mitochondria has been studied. The o -hydroxylated amines inhibited oxygen uptake in the presence of nicotinamide adenine dinucleotide-dependent respiratory substrates. Of the other compounds only 1-amino-4-naphthol inhibited oxygen uptake. The succinate oxidase system was inhibited only by 1-amino-2-naphthol and 1-amino-4-naphthol. The o -hydroxylated compounds impaired the efficiency of oxidative phosphorylation; the effect of 4-amino-3-hydroxybiphenyl was much more evident when -oxoglutarate was used as respiratory substrate. 1-Amino-2-naphthol and 1-amino-4-naphthol completely suppressed phosphate esterification. 1,2-Naphthoquinone and 1,4-naphthoquinone impaired the efficiency of oxidative phosphorylation when supported either by ß-hydroxybutyrate or by succinate. o -Aminophenol, 4-amino-3-hydroxybiphenyl, and 2-amino-1-naphthol stimulated mitochondrial adenosine triphosphatase in the presence of Mg ++ ; the last two compounds inhibited the dinitrophenol-induced adenosine triphosphatase activity. 1-Amino-2-naphthol and 1-amino-4-naphthol inhibited adenosine triphosphatase in the presence of Mg ++ and Mg ++ plus 2,4-dinitrophenol. 1 This work was partially supported by a grant from Consiglio Nazionale Delle Ricerche, Impresa di Enzimologia, Italy. 2 Present address: Chelsea College of Science and Technology, School of Pharmacy, 271/3 King St. Hammersmith, London W.6, England.

Journal

Cancer ResearchAmerican Association of Cancer Research

Published: Apr 1, 1967

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