The Path Well Traveled: Using Mammalian Retroviruses to Guide Research on XMRV
Abstract
The Path Well Traveled: Using Mammalian Retroviruses to Guide Research on XMRV — MI var callbackToken='473A71CC87662C6'; Skip to main page content HOME CURRENT ISSUE ARCHIVE FEEDBACK SUBSCRIPTIONS ALERTS HELP Keywords GO Advanced » Institution: DeepDyve User Name Password Sign In The Path Well Traveled: Using Mammalian Retroviruses to Guide Research on XMRV KyeongEun Lee 1 and Kathryn S. Jones 2 1 Model Development Section, HIV Drug Resistance Program, Center for Cancer Research, National Cancer Institute–Frederick, Frederick, Maryland 21702 2 Basic Science Program, Science Applications International Corporation–Frederick, Frederick, Maryland 21702 Since their discovery thirty years ago ( 1 ) , human retroviruses have become a major worldwide health concern. Human immunodeficiency virus type 1 (HIV-1), which infects approximately thirty-three million individuals, is the causative agent of AIDS and is also associated with neoplasia and neurologic disease. Another 10–20 million people are infected with a different retrovirus, human T cell leukemia virus type 1 (HTLV-1), which is the cause of adult T-cell leukemia/lymphoma (ATL) and several inflammatory disorders, including a progressive neurological disorder (HTLV-1-associated myelopathy/tropical spastic paraparesis; HAM/TSP) ( 2 ) . Recently, a previously unknown retrovirus, xenotropic murine leukemia virus-related virus (XMRV), was detected in human tissue ( 3