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Prediction of In Vivo Hepatic Clearance and Half-Life of Drug Candidates in Human Using Chimeric Mice with Humanized Liver

Prediction of In Vivo Hepatic Clearance and Half-Life of Drug Candidates in Human Using Chimeric... Prediction of In Vivo Hepatic Clearance and Half-Life of Drug Candidates in Human Using Chimeric Mice with Humanized Liver var callbackToken='475EF2853697E65'; Skip to main page content HOME CURRENT ISSUE ARCHIVE FEEDBACK SUBSCRIPTIONS ALERTS HELP Keywords GO Advanced » Institution: DeepDyve Sign In as Member / Individual User Name Password Sign In Prediction of In Vivo Hepatic Clearance and Half-Life of Drug Candidates in Human Using Chimeric Mice with Humanized Liver Seigo Sanoh , Aya Horiguchi , Kazumi Sugihara , Yaichiro Kotake , Yoshitaka Tayama , Hiroki Ohshita , Chise Tateno , Toru Horie , Shigeyuki Kitamura and Shigeru Ohta Graduate School of Biomedical Sciences (S.S., A.H., Y.K., S.O.) and Liver Research Project Center, Hiroshima University, Hiroshima, Japan (C.T.); Faculty of Pharmaceutical Sciences, Hiroshima International University, Hiroshima, Japan (K.S., Y.T.); PXB Mouse Production Department (H.O.) and R&D Department (C.T.), PhoenixBio Co., Ltd., Hiroshima, Japan; DeThree Research Laboratories, Ibaraki, Japan (T.H.); and Nihon Pharmaceutical University, Saitama, Japan (S.K.) <h3>Address correspondence to:</h3> Dr. Seigo Sanoh, Graduate School of Biomedical Sciences, Hiroshima University, Kasumi 1-2-3, Minami-ku, Hiroshima 734-8553 Japan. E-mail: sanoh@hiroshima-u.ac.jp <h2>Abstract</h2> Accurate prediction of pharmacokinetics (PK) parameters in humans from animal data is difficult for various reasons, including species differences. However, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Drug Metabolism and Disposition Am. Soc for Pharma & Experimental Therapeutics

Prediction of In Vivo Hepatic Clearance and Half-Life of Drug Candidates in Human Using Chimeric Mice with Humanized Liver

Prediction of In Vivo Hepatic Clearance and Half-Life of Drug Candidates in Human Using Chimeric Mice with Humanized Liver

Drug Metabolism and Disposition , Volume 40 (2): 322 – Feb 1, 2012

Abstract

Prediction of In Vivo Hepatic Clearance and Half-Life of Drug Candidates in Human Using Chimeric Mice with Humanized Liver var callbackToken='475EF2853697E65'; Skip to main page content HOME CURRENT ISSUE ARCHIVE FEEDBACK SUBSCRIPTIONS ALERTS HELP Keywords GO Advanced » Institution: DeepDyve Sign In as Member / Individual User Name Password Sign In Prediction of In Vivo Hepatic Clearance and Half-Life of Drug Candidates in Human Using Chimeric Mice with Humanized Liver Seigo Sanoh , Aya Horiguchi , Kazumi Sugihara , Yaichiro Kotake , Yoshitaka Tayama , Hiroki Ohshita , Chise Tateno , Toru Horie , Shigeyuki Kitamura and Shigeru Ohta Graduate School of Biomedical Sciences (S.S., A.H., Y.K., S.O.) and Liver Research Project Center, Hiroshima University, Hiroshima, Japan (C.T.); Faculty of Pharmaceutical Sciences, Hiroshima International University, Hiroshima, Japan (K.S., Y.T.); PXB Mouse Production Department (H.O.) and R&D Department (C.T.), PhoenixBio Co., Ltd., Hiroshima, Japan; DeThree Research Laboratories, Ibaraki, Japan (T.H.); and Nihon Pharmaceutical University, Saitama, Japan (S.K.) <h3>Address correspondence to:</h3> Dr. Seigo Sanoh, Graduate School of Biomedical Sciences, Hiroshima University, Kasumi 1-2-3, Minami-ku, Hiroshima 734-8553 Japan. E-mail: sanoh@hiroshima-u.ac.jp <h2>Abstract</h2> Accurate prediction of pharmacokinetics (PK) parameters in humans from animal data is difficult for various reasons, including species differences. However,

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References (41)

Publisher
Am. Soc for Pharma & Experimental Therapeutics
Copyright
Copyright © Drug Metabolism and Disposition
ISSN
0090-9556
eISSN
1521-009X
DOI
10.1124/dmd.111.040923
pmid
22048522
Publisher site
See Article on Publisher Site

Abstract

Prediction of In Vivo Hepatic Clearance and Half-Life of Drug Candidates in Human Using Chimeric Mice with Humanized Liver var callbackToken='475EF2853697E65'; Skip to main page content HOME CURRENT ISSUE ARCHIVE FEEDBACK SUBSCRIPTIONS ALERTS HELP Keywords GO Advanced » Institution: DeepDyve Sign In as Member / Individual User Name Password Sign In Prediction of In Vivo Hepatic Clearance and Half-Life of Drug Candidates in Human Using Chimeric Mice with Humanized Liver Seigo Sanoh , Aya Horiguchi , Kazumi Sugihara , Yaichiro Kotake , Yoshitaka Tayama , Hiroki Ohshita , Chise Tateno , Toru Horie , Shigeyuki Kitamura and Shigeru Ohta Graduate School of Biomedical Sciences (S.S., A.H., Y.K., S.O.) and Liver Research Project Center, Hiroshima University, Hiroshima, Japan (C.T.); Faculty of Pharmaceutical Sciences, Hiroshima International University, Hiroshima, Japan (K.S., Y.T.); PXB Mouse Production Department (H.O.) and R&D Department (C.T.), PhoenixBio Co., Ltd., Hiroshima, Japan; DeThree Research Laboratories, Ibaraki, Japan (T.H.); and Nihon Pharmaceutical University, Saitama, Japan (S.K.) <h3>Address correspondence to:</h3> Dr. Seigo Sanoh, Graduate School of Biomedical Sciences, Hiroshima University, Kasumi 1-2-3, Minami-ku, Hiroshima 734-8553 Japan. E-mail: sanoh@hiroshima-u.ac.jp <h2>Abstract</h2> Accurate prediction of pharmacokinetics (PK) parameters in humans from animal data is difficult for various reasons, including species differences. However,

Journal

Drug Metabolism and DispositionAm. Soc for Pharma & Experimental Therapeutics

Published: Feb 1, 2012

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