-
(2007)
Pharmacol Exp Ther 295:463-473
-
S.
Kitamura,
Kayoko
Nitta,
Y.
Tayama,
Chiaki
Tanoue,
K.
Sugihara,
Tae
Inoue,
T.
Horie,
S.
Ohta
(2008)
Aldehyde Oxidase-Catalyzed Metabolism of N1-Methylnicotinamide in Vivo and in Vitro in Chimeric Mice with Humanized Liver
Drug Metabolism and Disposition, 36
-
K.
Tabata,
Nozomu
Hamakawa,
S.
Sanoh,
S.
Terashita,
T.
Teramura
(2009)
Exploratory population pharmacokinetics (e-PPK) analysis for predicting human PK using exploratory ADME data during early drug discovery research
European Journal of Drug Metabolism and Pharmacokinetics, 34
-
Yoichi
Naritomi,
S.
Terashita,
A.
Kagayama,
Y.
Sugiyama
(2003)
Utility of hepatocytes in predicting drug metabolism: comparison of hepatic intrinsic clearance in rats and humans in vivo and in vitro.
Drug metabolism and disposition: the biological fate of chemicals, 31 5
-
DMD # 40923 5 the PK characteristics of candidate drugs in humans
-
M.
Serres,
G.
Bowers,
G.
Boyle,
C.
Beaumont,
S.
Castellino,
J.
Sigafoos,
M.
Dave,
Andrew
Roberts,
Vishal
Shah,
K.
Olson,
Dipak
Patel,
D.
Wagner,
R.
Yeager,
C.
Serabjit-Singh
(2011)
Evaluation of a chimeric (uPA+/+)/SCID mouse model with a humanized liver for prediction of human metabolism
Xenobiotica, 41
-
Qing
Wang,
Richard
Jia,
Cindy
Ye,
Martha
Garcia,
Jibin
Li,
I.
Hidalgo
(2005)
Glucuronidation and sulfation of 7-hydroxycoumarin in liver matrices from human, dog, monkey, rat, and mouse
In Vitro Cellular & Developmental Biology - Animal, 41
-
R.
Obach,
F.
Lombardo,
N.
Waters
(2008)
Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 670 Drug Compounds
Drug Metabolism and Disposition, 36
-
Hayley
Brown,
M.
Griffin,
J.
Houston
(2007)
Evaluation of Cryopreserved Human Hepatocytes as an Alternative in Vitro System to Microsomes for the Prediction of Metabolic Clearance
Drug Metabolism and Disposition, 35
-
W.
Chiou,
P.
Buehler
(2002)
Comparison of Oral Absorption and Bioavailability of Drugs Between Monkey and Human
Pharmaceutical Research, 19
-
(2010)
Evaluation of chimeric mice with humanized liver to predict human intrinsic clearance of drug molecules at preclinical phase
-
This research was supported by a Grant-in-Aid for Young Scientists (B) from for the Promotion of Science [Grant 22790109]; and
-
Michael
Zientek,
Ying
Jiang,
K.
Youdim,
R.
Obach
(2010)
In Vitro-In Vivo Correlation for Intrinsic Clearance for Drugs Metabolized by Human Aldehyde Oxidase
Drug Metabolism and Disposition, 38
-
T.
Akabane,
K.
Tabata,
K.
Kadono,
S.
Sakuda,
S.
Terashita,
T.
Teramura
(2010)
A Comparison of Pharmacokinetics between Humans and Monkeys
Drug Metabolism and Disposition, 38
-
Liyue
Huang,
L.
Berry,
S.
Ganga,
Brett
Janosky,
April
Chen,
Jonathan
Roberts,
A.
Colletti,
Min-Hwa
Lin
(2010)
Relationship between Passive Permeability, Efflux, and Predictability of Clearance from In Vitro Metabolic Intrinsic Clearance
Drug Metabolism and Disposition, 38
-
R.
Nagilla,
Kelly
Frank,
L.
Jolivette,
K.
Ward
(2006)
Investigation of the utility of published in vitro intrinsic clearance data for prediction of in vivo clearance.
Journal of pharmacological and toxicological methods, 53 2
-
H.
Yamazaki,
S.
Kuribayashi,
Tae
Inoue,
C.
Tateno,
Yasufumi
Nishikura,
K.
Oofusa,
D.
Harada,
S.
Naito,
T.
Horie,
S.
Ohta
(2010)
Approach for in vivo protein binding of 5-n-butyl-pyrazolo[1,5-a]pyrimidine bioactivated in chimeric mice with humanized liver by two-dimensional electrophoresis with accelerator mass spectrometry.
Chemical research in toxicology, 23 1
-
M.
Nishimura,
H.
Yoshitsugu,
Tsuyoshi
Yokoi,
C.
Tateno,
M.
Kataoka,
Toru
Horie,
K.
Yoshizato,
Shinsaku
Naito
(2005)
Evaluation of mRNA expression of human drug-metabolizing enzymes and transporters in chimeric mouse with humanized liver
Xenobiotica, 35
-
Compounds for which literature data were not available were excluded from this solid line represents unity
-
M.
Katoh,
Tomohito
Matsui,
M.
Nakajima,
C.
Tateno,
M.
Kataoka,
Y.
Soeno,
T.
Horie,
K.
Iwasaki,
K.
Yoshizato,
T.
Yokoi
(2004)
EXPRESSION OF HUMAN CYTOCHROMES P450 IN CHIMERIC MICE WITH HUMANIZED LIVER
Drug Metabolism and Disposition, 32
-
H.
Kamimura,
Naoyuki
Nakada,
Katsuhiro
Suzuki,
A.
Mera,
Kinya
Souda,
Y.
Murakami,
Kohichiro
Tanaka,
T.
Iwatsubo,
A.
Kawamura,
T.
Usui
(2010)
Assessment of chimeric mice with humanized liver as a tool for predicting circulating human metabolites.
Drug metabolism and pharmacokinetics, 25 3
-
S.
Buck,
Vikash
Sinha,
L.
Fenu,
M.
Nijsen,
C.
Mackie,
R.
Gilissen
(2007)
Prediction of Human Pharmacokinetics Using Physiologically Based Modeling: A Retrospective Analysis of 26 Clinically Tested Drugs
Drug Metabolism and Disposition, 35
-
M.
Katoh,
Tomohito
Matsui,
Hirotoshi
Okumura,
M.
Nakajima,
M.
Nishimura,
S.
Naito,
C.
Tateno,
K.
Yoshizato,
T.
Yokoi
(2005)
EXPRESSION OF HUMAN PHASE II ENZYMES IN CHIMERIC MICE WITH HUMANIZED LIVER
Drug Metabolism and Disposition, 33
-
S.
Ekins,
R.
Obach
(2000)
Three-dimensional quantitative structure activity relationship computational approaches for prediction of human in vitro intrinsic clearance.
The Journal of pharmacology and experimental therapeutics, 295 2
-
R.
Obach
(1999)
Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: An examination of in vitro half-life approach and nonspecific binding to microsomes.
Drug metabolism and disposition: the biological fate of chemicals, 27 11
-
C.
Yamasaki,
M.
Kataoka,
Y.
Kato,
Masakazu
Kakuni,
S.
Usuda,
Y.
Ohzone,
Sunao
Matsuda,
Y.
Adachi,
S.
Ninomiya,
T.
Itamoto,
T.
Asahara,
K.
Yoshizato,
C.
Tateno
(2010)
In vitro evaluation of cytochrome P450 and glucuronidation activities in hepatocytes isolated from liver-humanized mice.
Drug metabolism and pharmacokinetics, 25 6
-
H.
Yoshitsugu,
M.
Nishimura,
C.
Tateno,
M.
Kataoka,
E.
Takahashi,
Y.
Soeno,
K.
Yoshizato,
T.
Yokoi,
S.
Naito
(2006)
Evaluation of human CYP1A2 and CYP3A4 mRNA expression in hepatocytes from chimeric mice with humanized liver.
Drug metabolism and pharmacokinetics, 21 6
-
C.
Tateno,
Y.
Yoshizane,
N.
Saito,
M.
Kataoka,
R.
Utoh,
C.
Yamasaki,
Asato
Tachibana,
Y.
Soeno,
K.
Asahina,
H.
Hino,
T.
Asahara,
T.
Yokoi,
T.
Furukawa,
K.
Yoshizato
(2004)
Near completely humanized liver in mice shows human-type metabolic responses to drugs.
The American journal of pathology, 165 3
-
U.
Fagerholm
(2007)
Prediction of human pharmacokinetics—evaluation of methods for prediction of hepatic metabolic clearance
Journal of Pharmacy and Pharmacology, 59
-
Tae
Inoue,
K.
Sugihara,
H.
Ohshita,
T.
Horie,
S.
Kitamura,
S.
Ohta
(2009)
Prediction of human disposition toward S-3H-warfarin using chimeric mice with humanized liver.
Drug metabolism and pharmacokinetics, 24 2
-
R.
Stringer,
P.
Nicklin,
J.
Houston
(2008)
Reliability of human cryopreserved hepatocytes and liver microsomes as in vitro systems to predict metabolic clearance.
Xenobiotica; the fate of foreign compounds in biological systems, 38 10
-
M.
Chiba,
Y.
Ishii,
Y.
Sugiyama
(2009)
Prediction of Hepatic Clearance in Human From In Vitro Data for Successful Drug Development
The AAPS Journal, 11
-
W.
Chiou,
Hyunyoung
Jeong,
Sang
Chung,
Ta-Chen
Wu
(2000)
Evaluation of Using Dog as an Animal Model to Study the Fraction of Oral Dose Absorbed of 43 Drugs in Humans
Pharmaceutical Research, 17
-
PXB mice at 0.3-5 mg/kg body weight. The values of replacement index (RI) of PXB mice were ranged from 73
-
D.
Mcginnity,
M.
Soars,
R.
Urbanowicz,
R.
Riley
(2004)
EVALUATION OF FRESH AND CRYOPRESERVED HEPATOCYTES AS IN VITRO DRUG METABOLISM TOOLS FOR THE PREDICTION OF METABOLIC CLEARANCE
Drug Metabolism and Disposition, 32
-
B.
Davies,
T.
Morris
(1993)
Physiological Parameters in Laboratory Animals and Humans
Pharmaceutical Research, 10
-
polyethylene glycol 400; h-hepatocytes, PXB mice hepatocytes;
-
Performed data analisis : Sanoh, Horiguchi Wrote or contributed to the writing of the manuscript : Sanoh, Kotake, Tateno, and Ohta
-
K.
Pang,
M.
Rowland
(1977)
Hepatic clearance of drugs. I. Theoretical considerations of a “well-stirred” model and a “parallel tube” model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance
Journal of Pharmacokinetics and Biopharmaceutics, 5
-
P.
Paixão,
L.
Gouveia,
J.
Morais
(2010)
Prediction of the in vitro intrinsic clearance determined in suspensions of human hepatocytes by using artificial neural networks.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 39 5
-
D.
Hallifax,
Joanne
Foster,
J.
Houston
(2010)
Prediction of Human Metabolic Clearance from In Vitro Systems: Retrospective Analysis and Prospective View
Pharmaceutical Research, 27