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Emerging concepts from the recent literature

Emerging concepts from the recent literature Emerging concepts from the recent literature — MI var callbackToken='4736927C71CE219'; Skip to main page content HOME CURRENT ISSUE ARCHIVE FEEDBACK SUBSCRIPTIONS ALERTS HELP Keywords GO Advanced » Institution: DeepDyve User Name Password Sign In Emerging concepts from the recent literature <h2>Hydrogen Sulfide as Hypertension Regulator</h2> Hypertension is one of the risk factors for stroke, heart disease, and heart failure—serious causes of morbidity and mortality in the developing world. Hydrogen sulfide (H 2 S) has previously been shown to promote vascular relaxation and thereby decrease blood pressure; however, the origin of endogeneous H 2 S and the mechanism of action have remained unclear. In the June issue of JPET, Xia et al. identify two enzymes, cystathionine β-synthetase (CBS) and cystathionine γ-lyase (CGL), as producers of H 2 S in the kidney. Using a rat model of renal function, the authors demonstrate H 2 S production by these enzymes and present evidence that H 2 S may act through inhibition of a Na + /K + /2Cl − cotransporter and a Na + /K + /ATPase. This report provides insight into the underlying mechanism of H 2 S control of blood pressure regulation and opens the way for further understanding http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Molecular Interventions Am. Soc for Pharma & Experimental Therapeutics

Emerging concepts from the recent literature

Molecular Interventions , Volume 9 (4): 167 – Aug 1, 2009

Emerging concepts from the recent literature

Molecular Interventions , Volume 9 (4): 167 – Aug 1, 2009

Abstract

Emerging concepts from the recent literature — MI var callbackToken='4736927C71CE219'; Skip to main page content HOME CURRENT ISSUE ARCHIVE FEEDBACK SUBSCRIPTIONS ALERTS HELP Keywords GO Advanced » Institution: DeepDyve User Name Password Sign In Emerging concepts from the recent literature <h2>Hydrogen Sulfide as Hypertension Regulator</h2> Hypertension is one of the risk factors for stroke, heart disease, and heart failure—serious causes of morbidity and mortality in the developing world. Hydrogen sulfide (H 2 S) has previously been shown to promote vascular relaxation and thereby decrease blood pressure; however, the origin of endogeneous H 2 S and the mechanism of action have remained unclear. In the June issue of JPET, Xia et al. identify two enzymes, cystathionine β-synthetase (CBS) and cystathionine γ-lyase (CGL), as producers of H 2 S in the kidney. Using a rat model of renal function, the authors demonstrate H 2 S production by these enzymes and present evidence that H 2 S may act through inhibition of a Na + /K + /2Cl − cotransporter and a Na + /K + /ATPase. This report provides insight into the underlying mechanism of H 2 S control of blood pressure regulation and opens the way for further understanding

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Publisher
Am. Soc for Pharma & Experimental Therapeutics
Copyright
Copyright © Molecular Interventions
ISSN
1534-0384
eISSN
1543-2548
DOI
10.1124/mi.9.4.3
Publisher site
See Article on Publisher Site

Abstract

Emerging concepts from the recent literature — MI var callbackToken='4736927C71CE219'; Skip to main page content HOME CURRENT ISSUE ARCHIVE FEEDBACK SUBSCRIPTIONS ALERTS HELP Keywords GO Advanced » Institution: DeepDyve User Name Password Sign In Emerging concepts from the recent literature <h2>Hydrogen Sulfide as Hypertension Regulator</h2> Hypertension is one of the risk factors for stroke, heart disease, and heart failure—serious causes of morbidity and mortality in the developing world. Hydrogen sulfide (H 2 S) has previously been shown to promote vascular relaxation and thereby decrease blood pressure; however, the origin of endogeneous H 2 S and the mechanism of action have remained unclear. In the June issue of JPET, Xia et al. identify two enzymes, cystathionine β-synthetase (CBS) and cystathionine γ-lyase (CGL), as producers of H 2 S in the kidney. Using a rat model of renal function, the authors demonstrate H 2 S production by these enzymes and present evidence that H 2 S may act through inhibition of a Na + /K + /2Cl − cotransporter and a Na + /K + /ATPase. This report provides insight into the underlying mechanism of H 2 S control of blood pressure regulation and opens the way for further understanding

Journal

Molecular InterventionsAm. Soc for Pharma & Experimental Therapeutics

Published: Aug 1, 2009

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