Emerging concepts from the recent literature
Abstract
Emerging concepts from the recent literature — MI var callbackToken='4736927C71CE219'; Skip to main page content HOME CURRENT ISSUE ARCHIVE FEEDBACK SUBSCRIPTIONS ALERTS HELP Keywords GO Advanced » Institution: DeepDyve User Name Password Sign In Emerging concepts from the recent literature <h2>Hydrogen Sulfide as Hypertension Regulator</h2> Hypertension is one of the risk factors for stroke, heart disease, and heart failure—serious causes of morbidity and mortality in the developing world. Hydrogen sulfide (H 2 S) has previously been shown to promote vascular relaxation and thereby decrease blood pressure; however, the origin of endogeneous H 2 S and the mechanism of action have remained unclear. In the June issue of JPET, Xia et al. identify two enzymes, cystathionine β-synthetase (CBS) and cystathionine γ-lyase (CGL), as producers of H 2 S in the kidney. Using a rat model of renal function, the authors demonstrate H 2 S production by these enzymes and present evidence that H 2 S may act through inhibition of a Na + /K + /2Cl − cotransporter and a Na + /K + /ATPase. This report provides insight into the underlying mechanism of H 2 S control of blood pressure regulation and opens the way for further understanding