Effects of the CYP2B6*6 Allele on Catalytic Properties and Inhibition of CYP2B6 In Vitro: Implication for the Mechanism of Reduced Efavirenz Metabolism and Other CYP2B6 Substrates In Vivo
Abstract
Effects of the CYP2B6*6 Allele on Catalytic Properties and Inhibition of CYP2B6 In Vitro: Implication for the Mechanism of Reduced Efavirenz Metabolism and Other CYP2B6 Substrates In Vivo var callbackToken='475CF6F0D57CB3A'; Skip to main page content HOME CURRENT ISSUE ARCHIVE FEEDBACK SUBSCRIPTIONS ALERTS HELP Keywords GO Advanced » Institution: DeepDyve Sign In as Member / Individual User Name Password Sign In Effects of the CYP2B6 * 6 Allele on Catalytic Properties and Inhibition of CYP2B6 In Vitro: Implication for the Mechanism of Reduced Efavirenz Metabolism and Other CYP2B6 Substrates In Vivo Cong Xu , Evan T. Ogburn 1 , Yingying Guo and Zeruesenay Desta Indiana University School of Medicine, Indianapolis, Indiana (C.X., E.T.O., Z.D.); and Drug Disposition Laboratories and Business Operations, Lilly Research Laboratories, Indianapolis, Indiana (Y.G.) <h3>Address correspondence to:</h3> Dr. Zeruesenay Desta, Associate Professor of Medicine, Pharmacology and Toxicology, Department of Medicine/Division of Clinical Pharmacology, Indiana University School of Medicine, 1001 West 10th Street, WD Myers Bldg., W7123, Indianapolis, IN 46202. E-mail: zdesta@iupui.edu ↵ 1 Current affiliation: SSCI, West Lafayette, Indiana. <h2>Abstract</h2> The mechanism by which CYP2B6 * 6 allele alters drug metabolism in vitro and in vivo is not fully understood. To test the hypothesis that altered