An Evaluation of the Dilution Method for Identifying Metabolism-Dependent Inhibitors of Cytochrome P450 Enzymes
Abstract
An Evaluation of the Dilution Method for Identifying Metabolism-Dependent Inhibitors of Cytochrome P450 Enzymes var callbackToken='47517168E5DDDA5'; Skip to main page content HOME CURRENT ISSUE ARCHIVE FEEDBACK SUBSCRIPTIONS ALERTS HELP Keywords GO Advanced » Institution: DeepDyve Sign In as Member / Individual User Name Password Sign In An Evaluation of the Dilution Method for Identifying Metabolism-Dependent Inhibitors of Cytochrome P450 Enzymes Andrew Parkinson , Faraz Kazmi , David B. Buckley , Phyllis Yerino , Brandy L. Paris , Jeff Holsapple , Paul Toren , Steve M. Otradovec and Brian W. Ogilvie XenoTech, LLC, Lenexa, Kansas <h3>Address correspondence to:</h3> Dr. Andrew Parkinson, XenoTech, LLC, 16825 West 116th Street, Lenexa, KS 66219. E-mail: aparkinson@xenotechllc.com Parts of this work were previously presented at the following meetings: Parkinson A (2009) Metabolism-dependent inhibition (MDI) studies: ten things worth knowing and Paris BL, Kazmi F, Buckley DB, Ogilvie BW, Gipson AE, and Parkinson A (2009) Pitfalls in the design of CYP inhibition studies incorporating a dilution step to examine time-dependent inhibition (TDI) or metabolism-dependent inhibition (MDI). Sixteenth North American Regional ISSX Meeting ; 2009 Oct 18–22; Baltimore, MD. International Society for the Study of Xenobiotics, Washington, DC; Buckley DB, Kazmi F, Yerino P, Toren P,