Accessory Proteins in the Biogenesis of G Protein-Coupled Receptors
Abstract
Abstract Intracellular accessory proteins can be critical for G protein–coupled receptor (GPCR) biogenesis, including aspects of GPCR trafficking. Recent discoveries include the identification of multiple membrane-associated proteins that dictate not only the intracellular sequestration and/or transport of GPCRs, but also modulate—quite dramatically—GPCR ligand specificity subsequent to delivery to the cell surface. These exciting discoveries have shifted earlier paradigms of GPCR functionality.