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A “Wringing” Endorsement for Myosin Phosphorylation in the Heart

A “Wringing” Endorsement for Myosin Phosphorylation in the Heart Abstract On average, the human heart beats 100,000 times a day and it is in a person’s best interest to have the heart move blood as efficiently as possible. For example, imagine a wet rag: squeezing the rag in your fist does not remove as much water as wringing the same rag between two hands. Thus, in hearts as in rags, torsional wringing, as opposed to squeezing, more thoroughly empties the heart of blood. Recent reports indicate that the activity and the distribution of myosin light chain kinase (MLCK) in the myocardium is key to this process. MLCK-dependent phosphorylation of the regulatory light chain (R-LC), a subunit of the myosin molecule, may lead to increased force and power of contraction. It is the asymmetric distribution of MLCK in the myocardium that allows for torsional wringing rather than squeezing. Specifically targeting MLCK expression in the heart might, in the future, lead to promising therapies that counteract cardiomyopathy. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Molecular Interventions Am. Soc for Pharma & Experimental Therapeutics

A “Wringing” Endorsement for Myosin Phosphorylation in the Heart

Molecular Interventions , Volume 2 (7): 422 – Nov 1, 2002

A “Wringing” Endorsement for Myosin Phosphorylation in the Heart

Molecular Interventions , Volume 2 (7): 422 – Nov 1, 2002

Abstract

Abstract On average, the human heart beats 100,000 times a day and it is in a person’s best interest to have the heart move blood as efficiently as possible. For example, imagine a wet rag: squeezing the rag in your fist does not remove as much water as wringing the same rag between two hands. Thus, in hearts as in rags, torsional wringing, as opposed to squeezing, more thoroughly empties the heart of blood. Recent reports indicate that the activity and the distribution of myosin light chain kinase (MLCK) in the myocardium is key to this process. MLCK-dependent phosphorylation of the regulatory light chain (R-LC), a subunit of the myosin molecule, may lead to increased force and power of contraction. It is the asymmetric distribution of MLCK in the myocardium that allows for torsional wringing rather than squeezing. Specifically targeting MLCK expression in the heart might, in the future, lead to promising therapies that counteract cardiomyopathy.

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References (64)

Publisher
Am. Soc for Pharma & Experimental Therapeutics
Copyright
Copyright © Molecular Interventions
ISSN
1534-0384
eISSN
1543-2548
DOI
10.1124/mi.2.7.422
pmid
14993403
Publisher site
See Article on Publisher Site

Abstract

Abstract On average, the human heart beats 100,000 times a day and it is in a person’s best interest to have the heart move blood as efficiently as possible. For example, imagine a wet rag: squeezing the rag in your fist does not remove as much water as wringing the same rag between two hands. Thus, in hearts as in rags, torsional wringing, as opposed to squeezing, more thoroughly empties the heart of blood. Recent reports indicate that the activity and the distribution of myosin light chain kinase (MLCK) in the myocardium is key to this process. MLCK-dependent phosphorylation of the regulatory light chain (R-LC), a subunit of the myosin molecule, may lead to increased force and power of contraction. It is the asymmetric distribution of MLCK in the myocardium that allows for torsional wringing rather than squeezing. Specifically targeting MLCK expression in the heart might, in the future, lead to promising therapies that counteract cardiomyopathy.

Journal

Molecular InterventionsAm. Soc for Pharma & Experimental Therapeutics

Published: Nov 1, 2002

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