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Antidepressant research in the era of functional genomics: Farewell to the monoamine hypothesis

Antidepressant research in the era of functional genomics: Farewell to the monoamine hypothesis Biogenic Amines , Vol. 18, No. 3-6, pp. 275 – 290 (2004)  VSP 2004. Also available online - www.vsppub.com Antidepressant research in the era of functional genomics: Farewell to the monoamine hypothesis MISA YAMADA 1 , KOU TAKAHASHI 1 , MIKA TSUNODA 1 , TOMOKO IWABUCHI 1 , SHINYA KOBAYASHI 1 , NATSUKO TSUKAHARA 1 , TOMOYUKI NAKAGAWA 1 , MARI AWATSU 1 , SATORU YAMAZAKI 1 , MIHO HIRANO 1 , HISAYUKI OHATA 1 , GENTARO NISHIOKA 2 , KENTARO KUDO 2 , SATOSHI TANAKA 2 , KUNITOSHI KAMIJIMA 2 , TERUHIKO HIGUCHI 3 , KAZUTAKA MOMOSE 1 and MITSUHIKO YAMADA 4 , ∗ 1 Department of Pharmacology, School of Pharmaceutical Sciences, Showa University, Tokyo 142-8555, Japan 2 Department of Psychiatry, School of Medicine, Showa University, Tokyo 142-8555, Japan 3 Musashi Hospital, National Center of Neurology and Psychiatry, Tokyo 187-8551, Japan 4 Division of Psychogeriatrics, National Institute of Mental Health, National Center of Neurology and Psychiatry, 1-7-3 Kohuodai, Ichikawa, Chiba 272-0827, Japan Abstract —Although blockade by antidepressants of monoamine uptake into nerve endings is one of the cornerstones of the monoamine hypothesis of depression, there is a clear discrepancy between the rapid effects of antidepressants in http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Biogenic Amines Brill

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Publisher
Brill
Copyright
© 2004 Koninklijke Brill NV, Leiden, The Netherlands
ISSN
0168-8561
eISSN
1569-3910
DOI
10.1163/1569391041501898
Publisher site
See Article on Publisher Site

Abstract

Biogenic Amines , Vol. 18, No. 3-6, pp. 275 – 290 (2004)  VSP 2004. Also available online - www.vsppub.com Antidepressant research in the era of functional genomics: Farewell to the monoamine hypothesis MISA YAMADA 1 , KOU TAKAHASHI 1 , MIKA TSUNODA 1 , TOMOKO IWABUCHI 1 , SHINYA KOBAYASHI 1 , NATSUKO TSUKAHARA 1 , TOMOYUKI NAKAGAWA 1 , MARI AWATSU 1 , SATORU YAMAZAKI 1 , MIHO HIRANO 1 , HISAYUKI OHATA 1 , GENTARO NISHIOKA 2 , KENTARO KUDO 2 , SATOSHI TANAKA 2 , KUNITOSHI KAMIJIMA 2 , TERUHIKO HIGUCHI 3 , KAZUTAKA MOMOSE 1 and MITSUHIKO YAMADA 4 , ∗ 1 Department of Pharmacology, School of Pharmaceutical Sciences, Showa University, Tokyo 142-8555, Japan 2 Department of Psychiatry, School of Medicine, Showa University, Tokyo 142-8555, Japan 3 Musashi Hospital, National Center of Neurology and Psychiatry, Tokyo 187-8551, Japan 4 Division of Psychogeriatrics, National Institute of Mental Health, National Center of Neurology and Psychiatry, 1-7-3 Kohuodai, Ichikawa, Chiba 272-0827, Japan Abstract —Although blockade by antidepressants of monoamine uptake into nerve endings is one of the cornerstones of the monoamine hypothesis of depression, there is a clear discrepancy between the rapid effects of antidepressants in

Journal

Biogenic AminesBrill

Published: Jan 1, 2004

Keywords: DEPRESSION; ANTIDEPRESSANT; NEURAL PLASTICITY; MICROARRAY; DIFFERENTIAL CLONING

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