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The ferret: a cytotoxic drug-induced emesis model

The ferret: a cytotoxic drug-induced emesis model Biogenic Amines , Vol. 18, No. 3-6, pp. 419 – 434 (2004)  VSP 2004. Also available online - www.vsppub.com The ferret: a cytotoxic drug-induced emesis model T. ENDO 1 , ∗ , M. MINAMI 1 , M. HIRAFUJI 1 , N. HAMAUE 1 and S. H. PARVEZ 2 1 Department of Pharmacology, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Hokkaido 061-0293, Japan 2 Alfred Fressard Institute of Neuroscience, CNRS UPR 2212-Bât 5, Chateau CNRS 91190, Gif Sur Yvette, France Abstract —The ferret ( Mustela putorius furo ), a carnivore weighting 1–1.5 kg, is highly valued as a small animal model for determining the emetic activity of cytotoxic drugs. Because of its sensitivity to emetic stimuli, the ferret is now being used routinely for testing novel cytotoxic drugs and antiemetic agents. In our laboratory, ferrets were evaluated on their behavioral changes, pathological changes and pharmacological responses to cytotoxic drug-induced emesis. Cisplatin-induced emesis in ferrets was inhibited by 5-HT 3 receptor antagonists in a dose dependent manner. 5-HT levels in the area postrema and in the ileum were increased by cytotoxic agents. Both abdominal vagotomy and ondansetron, a 5-HT 3 receptor antagonist, remarkably inhibited cisplatin-induced emesis and cisplatin-induced increase in http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Biogenic Amines Brill

The ferret: a cytotoxic drug-induced emesis model

Endo; Hirafuji; Minami; Hamaue; Parvez
Biogenic Amines , Volume 18 (3): 419 – Jan 1, 2004
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Publisher
Brill
Copyright
© 2004 Koninklijke Brill NV, Leiden, The Netherlands
ISSN
0168-8561
eISSN
1569-3910
DOI
10.1163/1569391041501834
Publisher site
See Article on Publisher Site

Abstract

Biogenic Amines , Vol. 18, No. 3-6, pp. 419 – 434 (2004)  VSP 2004. Also available online - www.vsppub.com The ferret: a cytotoxic drug-induced emesis model T. ENDO 1 , ∗ , M. MINAMI 1 , M. HIRAFUJI 1 , N. HAMAUE 1 and S. H. PARVEZ 2 1 Department of Pharmacology, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Hokkaido 061-0293, Japan 2 Alfred Fressard Institute of Neuroscience, CNRS UPR 2212-Bât 5, Chateau CNRS 91190, Gif Sur Yvette, France Abstract —The ferret ( Mustela putorius furo ), a carnivore weighting 1–1.5 kg, is highly valued as a small animal model for determining the emetic activity of cytotoxic drugs. Because of its sensitivity to emetic stimuli, the ferret is now being used routinely for testing novel cytotoxic drugs and antiemetic agents. In our laboratory, ferrets were evaluated on their behavioral changes, pathological changes and pharmacological responses to cytotoxic drug-induced emesis. Cisplatin-induced emesis in ferrets was inhibited by 5-HT 3 receptor antagonists in a dose dependent manner. 5-HT levels in the area postrema and in the ileum were increased by cytotoxic agents. Both abdominal vagotomy and ondansetron, a 5-HT 3 receptor antagonist, remarkably inhibited cisplatin-induced emesis and cisplatin-induced increase in

Journal

Biogenic Amines – Brill

Published: Jan 1, 2004

Keywords: 5-HT; CISPLATIN; FERRET; EC CELLS; VAGUS AFFERENT

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