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Acute and chronic effects of tryptophan and alcohol on serotonin in the locus coeruleus in rats

Acute and chronic effects of tryptophan and alcohol on serotonin in the locus coeruleus in rats Biogenic Amines , Vol. 18, No. 3-6, pp. 291 – 306 (2004)  VSP 2004. Also available online - www.vsppub.com Acute and chronic effects of tryptophan and alcohol on serotonin in the locus coeruleus in rats K. HOSHI ∗ , M. HAYASHI and T. BANDOH Department of Clinical Pharmacology, Hokkaido College of Pharmacy, 7-1 Katsuraoka-cho, Otaru, Hokkaido 047-0264, Japan Abstract —The present review will concentrate on a discussion of recent investigations that demon- strated whether the levels of 5-hydroxytryptamine (serotonin; 5-HT) and its metabolite, 5-hydro- xyindoleacetic acid (5-HIAA), in the locus coeruleus are influenced by tryptophan alone or simul- taneous administration of tryptophan and ethanol. The impetus for this line of investigation derives from a report that mice treated with tryptophol plus alcohol increased brain tryptophol level and be- came highly susceptible to convulsions. A deficiency in 5-HT synthesis and metabolism (turnover) has been implicated in several neuropsychiatric disorders, including depression, obsessive-compulsive disorder, bulimia nervosa, late luteal phase dysphoric syndrome, alcoholism, impulsive violence and aggression. Emphasis will be placed on demonstration of a rodent model in which the tryptophan administration induces the increased 5-HIAA level through the activation of serotonergic neuronal system. The use of in vivo microdialysis http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Biogenic Amines Brill

Acute and chronic effects of tryptophan and alcohol on serotonin in the locus coeruleus in rats

Biogenic Amines , Volume 18 (3): 291 – Jan 1, 2004

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Publisher
Brill
Copyright
© 2004 Koninklijke Brill NV, Leiden, The Netherlands
ISSN
0168-8561
eISSN
1569-3910
DOI
10.1163/1569391041501780
Publisher site
See Article on Publisher Site

Abstract

Biogenic Amines , Vol. 18, No. 3-6, pp. 291 – 306 (2004)  VSP 2004. Also available online - www.vsppub.com Acute and chronic effects of tryptophan and alcohol on serotonin in the locus coeruleus in rats K. HOSHI ∗ , M. HAYASHI and T. BANDOH Department of Clinical Pharmacology, Hokkaido College of Pharmacy, 7-1 Katsuraoka-cho, Otaru, Hokkaido 047-0264, Japan Abstract —The present review will concentrate on a discussion of recent investigations that demon- strated whether the levels of 5-hydroxytryptamine (serotonin; 5-HT) and its metabolite, 5-hydro- xyindoleacetic acid (5-HIAA), in the locus coeruleus are influenced by tryptophan alone or simul- taneous administration of tryptophan and ethanol. The impetus for this line of investigation derives from a report that mice treated with tryptophol plus alcohol increased brain tryptophol level and be- came highly susceptible to convulsions. A deficiency in 5-HT synthesis and metabolism (turnover) has been implicated in several neuropsychiatric disorders, including depression, obsessive-compulsive disorder, bulimia nervosa, late luteal phase dysphoric syndrome, alcoholism, impulsive violence and aggression. Emphasis will be placed on demonstration of a rodent model in which the tryptophan administration induces the increased 5-HIAA level through the activation of serotonergic neuronal system. The use of in vivo microdialysis

Journal

Biogenic AminesBrill

Published: Jan 1, 2004

Keywords: MICRODIALYSIS; ALCOHOL; 5-HIAA; LOCUS COERULEUS; 5-HYDROXYINDOLEACETIC ACID; TRYPTOPHAN; DORSAL RAPHE NUCLEUS

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