Access the full text.
Sign up today, get DeepDyve free for 14 days.
References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.
Biogenic Amines , Vol. 18, No. 3-6, pp. 291 – 306 (2004) VSP 2004. Also available online - www.vsppub.com Acute and chronic effects of tryptophan and alcohol on serotonin in the locus coeruleus in rats K. HOSHI ∗ , M. HAYASHI and T. BANDOH Department of Clinical Pharmacology, Hokkaido College of Pharmacy, 7-1 Katsuraoka-cho, Otaru, Hokkaido 047-0264, Japan Abstract —The present review will concentrate on a discussion of recent investigations that demon- strated whether the levels of 5-hydroxytryptamine (serotonin; 5-HT) and its metabolite, 5-hydro- xyindoleacetic acid (5-HIAA), in the locus coeruleus are influenced by tryptophan alone or simul- taneous administration of tryptophan and ethanol. The impetus for this line of investigation derives from a report that mice treated with tryptophol plus alcohol increased brain tryptophol level and be- came highly susceptible to convulsions. A deficiency in 5-HT synthesis and metabolism (turnover) has been implicated in several neuropsychiatric disorders, including depression, obsessive-compulsive disorder, bulimia nervosa, late luteal phase dysphoric syndrome, alcoholism, impulsive violence and aggression. Emphasis will be placed on demonstration of a rodent model in which the tryptophan administration induces the increased 5-HIAA level through the activation of serotonergic neuronal system. The use of in vivo microdialysis
Biogenic Amines – Brill
Published: Jan 1, 2004
Keywords: MICRODIALYSIS; ALCOHOL; 5-HIAA; LOCUS COERULEUS; 5-HYDROXYINDOLEACETIC ACID; TRYPTOPHAN; DORSAL RAPHE NUCLEUS
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.