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Juvenile stroke-prone spontaneously hypertensive rats as an animal model of attention-deficit/hyperactivity disorder

Juvenile stroke-prone spontaneously hypertensive rats as an animal model of... Biogenic Amines , Vol. 17, No. 4-6, pp. 293– 312 (2003) Ó VSP 2003. Also available online - www.vsppub.com Juvenile stroke-prone spontaneously hypertensive rats as an animal model of attention-deŽ cit/ hyperactivity disorder KEN-ICHI UENO 1 ; ¤ , HIROKO TOGASHI 1 , MACHIKO MATSUMOTO 1 , HIDEYA SAITO 2 and MITSUHIRO YOSHIOKA 1 1 Department of Pharmacology, Hokkaido University School of Medicine, Kita-15, Nishi-7, Kita-ku, Sapporo 060-8638, Japan 2 Department of Basic Sciences, Japanese Red Cross Hokkaido College of Nursing, Kitami 090-0011, Japan Abstract —Attention-deŽ cit/hyperactivity disorder (AD /HD) is deŽ ned as a developmental disorder, manifested by inattention and/ or hyperactivity-impulsivity. Neuropsychological studies suggest impaired cognitive function including working memory. 3– 5% of school-aged children show signs of this disorder with male predominance. This article provides an overview of the symptomatic relevance of juvenile stroke-prone spontaneously hypertensive rats (SHRSP) as an animal model of AD/ HD. To characterize behavioral alterations, i.e. hyperactivity-impulsivityand/ or inattention, SHRSP were diagnosed according to motor activity, as well as emotional and cognitive behaviors with or without methylphenidate, a Ž rst choice drug for AD /HD therapy. Ambulatory and rearing activities in the open-Ž eld environment were signiŽ cantly higher in SHRSP http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Biogenic Amines Brill

Juvenile stroke-prone spontaneously hypertensive rats as an animal model of attention-deficit/hyperactivity disorder

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References (1)

Publisher
Brill
Copyright
© 2002 Koninklijke Brill NV, Leiden, The Netherlands
ISSN
0168-8561
eISSN
1569-3910
DOI
10.1163/15693910260698267
Publisher site
See Article on Publisher Site

Abstract

Biogenic Amines , Vol. 17, No. 4-6, pp. 293– 312 (2003) Ó VSP 2003. Also available online - www.vsppub.com Juvenile stroke-prone spontaneously hypertensive rats as an animal model of attention-deŽ cit/ hyperactivity disorder KEN-ICHI UENO 1 ; ¤ , HIROKO TOGASHI 1 , MACHIKO MATSUMOTO 1 , HIDEYA SAITO 2 and MITSUHIRO YOSHIOKA 1 1 Department of Pharmacology, Hokkaido University School of Medicine, Kita-15, Nishi-7, Kita-ku, Sapporo 060-8638, Japan 2 Department of Basic Sciences, Japanese Red Cross Hokkaido College of Nursing, Kitami 090-0011, Japan Abstract —Attention-deŽ cit/hyperactivity disorder (AD /HD) is deŽ ned as a developmental disorder, manifested by inattention and/ or hyperactivity-impulsivity. Neuropsychological studies suggest impaired cognitive function including working memory. 3– 5% of school-aged children show signs of this disorder with male predominance. This article provides an overview of the symptomatic relevance of juvenile stroke-prone spontaneously hypertensive rats (SHRSP) as an animal model of AD/ HD. To characterize behavioral alterations, i.e. hyperactivity-impulsivityand/ or inattention, SHRSP were diagnosed according to motor activity, as well as emotional and cognitive behaviors with or without methylphenidate, a Ž rst choice drug for AD /HD therapy. Ambulatory and rearing activities in the open-Ž eld environment were signiŽ cantly higher in SHRSP

Journal

Biogenic AminesBrill

Published: Jan 1, 2002

Keywords: STROKE-PRONE SPONTANEOUSLY; Y-MAZE; METHYLPHENIDATE; ELEVATED PLUS-MAZE; HYPERTENSIVE RATS SHRSP; ATTENTION-DEFICIT HYPERACTIVITY DISORDER AD HD; OPEN-FIELD

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