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M. Aman, Rosemary Marks, S. Turbott, C. Wilsher, S. Merry (1991)
Methylphenidate and thioridazine in the treatment of intellectually subaverage children: effects on cognitive-motor performance.Journal of the American Academy of Child and Adolescent Psychiatry, 30 5
Biogenic Amines , Vol. 17, No. 4-6, pp. 293– 312 (2003) Ó VSP 2003. Also available online - www.vsppub.com Juvenile stroke-prone spontaneously hypertensive rats as an animal model of attention-de cit/ hyperactivity disorder KEN-ICHI UENO 1 ; ¤ , HIROKO TOGASHI 1 , MACHIKO MATSUMOTO 1 , HIDEYA SAITO 2 and MITSUHIRO YOSHIOKA 1 1 Department of Pharmacology, Hokkaido University School of Medicine, Kita-15, Nishi-7, Kita-ku, Sapporo 060-8638, Japan 2 Department of Basic Sciences, Japanese Red Cross Hokkaido College of Nursing, Kitami 090-0011, Japan Abstract —Attention-de cit/hyperactivity disorder (AD /HD) is de ned as a developmental disorder, manifested by inattention and/ or hyperactivity-impulsivity. Neuropsychological studies suggest impaired cognitive function including working memory. 3– 5% of school-aged children show signs of this disorder with male predominance. This article provides an overview of the symptomatic relevance of juvenile stroke-prone spontaneously hypertensive rats (SHRSP) as an animal model of AD/ HD. To characterize behavioral alterations, i.e. hyperactivity-impulsivityand/ or inattention, SHRSP were diagnosed according to motor activity, as well as emotional and cognitive behaviors with or without methylphenidate, a rst choice drug for AD /HD therapy. Ambulatory and rearing activities in the open- eld environment were signi cantly higher in SHRSP
Biogenic Amines – Brill
Published: Jan 1, 2002
Keywords: STROKE-PRONE SPONTANEOUSLY; Y-MAZE; METHYLPHENIDATE; ELEVATED PLUS-MAZE; HYPERTENSIVE RATS SHRSP; ATTENTION-DEFICIT HYPERACTIVITY DISORDER AD HD; OPEN-FIELD
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