Access the full text.
Sign up today, get DeepDyve free for 14 days.
T. Greenley, M. Davies (1992)
Detection of radicals produced by reaction of hydroperoxides with rat liver microsomal fractions.Biochimica et biophysica acta, 1116 2
E. Newman, C. Rice-evans, M. Davies (1991)
Identification of initiating agents in myoglobin-induced lipid peroxidation.Biochemical and biophysical research communications, 179 3
P. Graceffa (1983)
Spin labeling of protein sulfhydryl groups by spin trapping a sulfur radical: application to bovine serum albumin and myosin.Archives of biochemistry and biophysics, 225 2
R. Dean, J. Gebicki, S. Gieseg, A. Grant, J. Simpson (1992)
Hypothesis: a damaging role in aging for reactive protein oxidation products?Mutation research, 275 3-6
J. Simpson, S. Narita, S. Gieseg, S. Gebicki, J. Gebicki, R. Dean (1992)
Long-lived reactive species on free-radical-damaged proteins.The Biochemical journal, 282 ( Pt 3)
C. Sonntag (1987)
The chemical basis of radiation biology
G. Buettner (1987)
Spin trapping: ESR parameters of spin adducts.Free radical biology & medicine, 3 4
S. Wolff, R. Dean (1986)
Fragmentation of proteins by free radicals and its effect on their susceptibility to enzymic hydrolysis.The Biochemical journal, 234 2
Michael Davies (1990)
Detection of myoglobin-derived radicals on reaction of metmyoglobin with hydrogen peroxide and other peroxidic compounds.Free radical research communications, 10 6
C. Rice-evans, A. Diplock, M. Symons (1991)
Techniques in Free Radical Research
K. Davies (1987)
Protein damage and degradation by oxygen radicals. I. general aspects.The Journal of biological chemistry, 262 20
M. Davies, T. Slater (1987)
Studies on the metal-ion and lipoxygenase-catalysed breakdown of hydroperoxides using electron-spin-resonance spectroscopy.The Biochemical journal, 245 1
K. Maples, C. Kennedy, S. Jordan, R. Mason (1990)
In vivo thiyl free radical formation from hemoglobin following administration of hydroperoxides.Archives of biochemistry and biophysics, 277 2
Michael Davies (1989)
Detection of peroxyl and alkoxyl radicals produced by reaction of hydroperoxides with rat liver microsomal fractions.The Biochemical journal, 257 2
K. Maples, S. Jordan, R. Mason (1988)
In vivo rat hemoglobin thiyl free radical formation following phenylhydrazine administration.Molecular pharmacology, 33 3
A. Carmichael (1990)
Vanadyl‐induced Fenton‐like reaction in RNAFEBS Letters, 261
M. Davies, B. Gilbert, R. Haywood (1991)
Radical-induced damage to proteins: e.s.r. spin-trapping studies.Free radical research communications, 15 2
K. Maples, P. Eyer, R. Mason (1990)
Aniline-, phenylhydroxylamine-, nitrosobenzene-, and nitrobenzene-induced hemoglobin thiyl free radical formation in vivo and in vitro.Molecular pharmacology, 37 2
EPR spectroscopy in conjunction with spin trapping has been employed extensively and successfully to detect and identify low-molecular-weight reactive radicals in biological systems. In contrast, this technique has been relatively infrequently used to investigate high-molecular-weight species generated as a result of radical-induced damage to biological macromolecules, such as DNA, RNA, proteins and carbohydrates, despite the fact that the destruction or alteration of these materials is known to play a key role in a large number of cellular injuries and diseases. Recent progress in the detection and identification of these macromolecular radicals by EPR spin trapping is reviewed, with particular emphasis on supplementary techniques which often yield valuable information as to the nature and identity of the species detected.
Research on Chemical Intermediates – Springer Journals
Published: Jan 1, 1993
Keywords: Adduct; Nitroxide; Spin Trap; Spin Adduct; Methaemoglobin
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.