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Ultrastructural localization of brain-derived neurotrophic factor in rat primary sensory neurons

Ultrastructural localization of brain-derived neurotrophic factor in rat primary sensory neurons Sensory Neuron , Vol. 3, No. 2, pp. 83– 95 (2000) Ó VSP 2000. Ultrastructural localization of brain-derived neurotrophic factor in rat primary sensory neurons XUE-GANG LUO ¤ , ROBERT A. RUSH and XIN-FU ZHOU ² Department of Human Physiology and Centre for Neuroscience, Flinders University of South Australia, GPO Box 2100, Adelaide 5001, Australia Abstract —In a previous study we have shown that brain-derived neurotrophic factor (BDNF) is present in a subpopulation of small to medium sized sensory neurons in the dorsal root ganglia (DRG), and is anterogradely transported in both the peripheral and central processes. Within the spinal cord, BDNF is localized to varicosities of sensory nerve terminals in laminae I and II of the dorsal horn. This study raised the question of whether BDNF is localized in synaptic vesicles of the afferent nerve terminals. Using immunohistochemical and immunocytochemical techniques we have now investigated the ultrastructural localization of BDNF in the spinal cord of the rat. In addition, its co-localization with the low-afŽ nity neurotrophin receptor, p75, and calcitonin gene-related peptide (CGRP) was also investigated. In lamina II of the spinal cord, BDNF immunoreactivity was restricted to nerve terminals. The antigen was mainly localized to dense-cored http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Sensory Neuron Brill

Ultrastructural localization of brain-derived neurotrophic factor in rat primary sensory neurons

Luo, Xue-Gang; ⋑, Xin-Fu Zhou; Rush, Robert
Sensory Neuron , Volume 3 (2): 83 – Jan 1, 2000
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Publisher
Brill
Copyright
© 2000 Koninklijke Brill NV, Leiden, The Netherlands
ISSN
1567-5157
eISSN
1568-5659
DOI
10.1163/156856500744757
Publisher site
See Article on Publisher Site

Abstract

Sensory Neuron , Vol. 3, No. 2, pp. 83– 95 (2000) Ó VSP 2000. Ultrastructural localization of brain-derived neurotrophic factor in rat primary sensory neurons XUE-GANG LUO ¤ , ROBERT A. RUSH and XIN-FU ZHOU ² Department of Human Physiology and Centre for Neuroscience, Flinders University of South Australia, GPO Box 2100, Adelaide 5001, Australia Abstract —In a previous study we have shown that brain-derived neurotrophic factor (BDNF) is present in a subpopulation of small to medium sized sensory neurons in the dorsal root ganglia (DRG), and is anterogradely transported in both the peripheral and central processes. Within the spinal cord, BDNF is localized to varicosities of sensory nerve terminals in laminae I and II of the dorsal horn. This study raised the question of whether BDNF is localized in synaptic vesicles of the afferent nerve terminals. Using immunohistochemical and immunocytochemical techniques we have now investigated the ultrastructural localization of BDNF in the spinal cord of the rat. In addition, its co-localization with the low-afŽ nity neurotrophin receptor, p75, and calcitonin gene-related peptide (CGRP) was also investigated. In lamina II of the spinal cord, BDNF immunoreactivity was restricted to nerve terminals. The antigen was mainly localized to dense-cored

Journal

Sensory Neuron – Brill

Published: Jan 1, 2000

Keywords: MITOCHONDRIA; VESICLES; P.75 LOW-AFFINITY NEUROTROPHIN RECEPTOR; SPINAL CORD; CALCITONIN GENE-RELATED PEPTIDE

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