Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

HLA immunization of haemodialysed patients in the transfusion and the erythropoietin eras

HLA immunization of haemodialysed patients in the transfusion and the erythropoietin eras Haematologia , Vol. 31, No. 3, pp. 257– 261 (2001) Ó VSP 2001. Paper HLA immunization of haemodialysed patients in the transfusion and the erythropoietin eras J. TOLDI ¤ and GY. GÁL Regional Transfusion Centre of the National Blood Transfusion Service, Szeged, Hungary Abstract —The frequency of transfusions and the development of HLA alloimmunization in the years 1986 and 1995, representing the ‘transfusion era’ and the ‘erythropoietin era’, have been compared. The introduction of erythropoietin was found to reduce the need for transfusion in haemodialysed patients on the waiting list from 65.2% to 5.7%. The elimination of transfusions resulted in a decrease in HLA immunization from 56.5% to 35%. In those patients who were still immunized, antibody production was probably caused either by immunomodulation or by transfusions given to treat complications. Erythropoietin could be used instead of transfusions in almost all cases, except for complications involving severe bleeding. Key words : Erythropoietin; haemodialysed patients; HLA immunization; transfusion. INTRODUCTION Until 1990, the only effective treatment for severe anaemia associated with chronic renal insufŽ ciency was transfusion. As a result of transfusions, the immune system of the patient often forms antibodies in response to the presence of foreign structures in http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Haematologia Brill

HLA immunization of haemodialysed patients in the transfusion and the erythropoietin eras

Gál; Toldi
Haematologia , Volume 31 (3): 257 – Jan 1, 2001
Download PDF
5 pages

Loading next page...
 
/lp/brill/hla-immunization-of-haemodialysed-patients-in-the-transfusion-and-the-o3eXlaHBlP

References

References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.

Publisher
Brill
Copyright
© 2001 Koninklijke Brill NV, Leiden, The Netherlands
ISSN
0017-6559
eISSN
1568-5594
DOI
10.1163/15685590152763818
Publisher site
See Article on Publisher Site

Abstract

Haematologia , Vol. 31, No. 3, pp. 257– 261 (2001) Ó VSP 2001. Paper HLA immunization of haemodialysed patients in the transfusion and the erythropoietin eras J. TOLDI ¤ and GY. GÁL Regional Transfusion Centre of the National Blood Transfusion Service, Szeged, Hungary Abstract —The frequency of transfusions and the development of HLA alloimmunization in the years 1986 and 1995, representing the ‘transfusion era’ and the ‘erythropoietin era’, have been compared. The introduction of erythropoietin was found to reduce the need for transfusion in haemodialysed patients on the waiting list from 65.2% to 5.7%. The elimination of transfusions resulted in a decrease in HLA immunization from 56.5% to 35%. In those patients who were still immunized, antibody production was probably caused either by immunomodulation or by transfusions given to treat complications. Erythropoietin could be used instead of transfusions in almost all cases, except for complications involving severe bleeding. Key words : Erythropoietin; haemodialysed patients; HLA immunization; transfusion. INTRODUCTION Until 1990, the only effective treatment for severe anaemia associated with chronic renal insufŽ ciency was transfusion. As a result of transfusions, the immune system of the patient often forms antibodies in response to the presence of foreign structures in

Journal

Haematologia – Brill

Published: Jan 1, 2001

Keywords: TRANSFUSION; ERYTHROPOIETIN; HAEMODIALYSED PATIENTS; HLA IMMUNIZATION

There are no references for this article.