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Haematologia , Vol. 31, No. 2, pp. 177– 179 (2001) Ó VSP 2001. Letter to the Editor Elevation of serum procalcitonin level in a patient with chronic myelocytic leukemia T. TAKUBO ¤ , T. KUMURA, K. OHTA, T. YAMANE, M. HINO, T. KAMITANI and N. TATSUMI Department of Clinical and Laboratory Medicine, Osaka City University Medical School, 1-4-3, Asahimachi, Abeno-ku, Osaka 545-8585, Japan Key words : Procalcitonin; chronic myelocytic leukemia. Procalcitonin (PCT) is produced in the thyroid gland as the precursor of human calcitonin [1]. PCT is a 116 amino acid protein with a molecular weight of approximately 13 kD and is composed of an N-terminal region, mid-regional calcitonin, and the C-terminal katacalcin [2]. Prehormone levels in serum have been found to be elevated in medullary thyroid carcinoma as well as in a large number of other tumors [4, 5]. C-reactive protein (CRP) is a typical marker of acute in ammation and bacterial infection [3]. Recently, PCT was found to be a new and innovative infection parameter [6], and to provide better diagnostic validity in the evaluation, monitoring and prognostic estimation of severe infections and sepsis than established in ammation parameters [7, 8]. We therefore investigated whether serum
Haematologia – Brill
Published: Jan 1, 2001
Keywords: PROCALCITONIN; CHRONIC MYELOCYTIC LEUKEMIA
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