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Presence of Pth-Like and Pth-Related Peptide-Like Molecules in Submammalian Vertebrates

Presence of Pth-Like and Pth-Related Peptide-Like Molecules in Submammalian Vertebrates PRESENCE OF PTH-LIKE AND PTH-RELATED PEPTIDE- LIKE MOLECULES IN SUBMAMMALIAN VERTEBRATES by NADÈGE CHAILLEUX*, CHRISTIAN MILET, ALENA VIDAL and EVELYNE LOPEZ (Laboratoire de Physiologie Générale el Comparée du Museum d'Histoire Naturelle, URA-CNRS 090, 7 rue Cuvier 75231 Paris Cedex 05, France) ABSTRACT The endocrine Stannius corpuscles (CS) of holostean and teleostean fishes produce molecules resembling mammalian parathyroid hormone (PTH). We have shown that extracts of eel CS contain proteins related to these PTH-related peptides (PTHrp) and, furthermore, that reptiles, amphibians, fish and Agnatha have DNA fragments homolo- gous to the chicken PTHrp gene. KEY WORDS: PTH, PTHrp, Stannius corpuscles, calcium regulation. Vertebrate tetrapods possess parathyroid glands secreting PTH, which controls the serum calcium concentration. In fish, these glands do not exist. However, holostean and teleostean fishes possess Stannius cor- puscles (CS), which produce factors that control serum calcium (FON- TAINr., 1964) by acting at the gills (MILE'R et al., 1979). A number of data suggest that these factors are functionnally and immunologically related to PTH: in the eel (Anguilla anguilla) removal of CS induces an increase in serum calcium concentration which is counteracted by injection of synthetic human PTH 1-34 (MILET et al., 1980). Further- more, antibodies raised http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Netherlands Journal of Zoology (in 2003 continued as Animal Biology) Brill

Presence of Pth-Like and Pth-Related Peptide-Like Molecules in Submammalian Vertebrates

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Publisher
Brill
Copyright
© 1994 Koninklijke Brill NV, Leiden, The Netherlands
ISSN
0028-2960
eISSN
1568-542X
DOI
10.1163/156854295X01040
Publisher site
See Article on Publisher Site

Abstract

PRESENCE OF PTH-LIKE AND PTH-RELATED PEPTIDE- LIKE MOLECULES IN SUBMAMMALIAN VERTEBRATES by NADÈGE CHAILLEUX*, CHRISTIAN MILET, ALENA VIDAL and EVELYNE LOPEZ (Laboratoire de Physiologie Générale el Comparée du Museum d'Histoire Naturelle, URA-CNRS 090, 7 rue Cuvier 75231 Paris Cedex 05, France) ABSTRACT The endocrine Stannius corpuscles (CS) of holostean and teleostean fishes produce molecules resembling mammalian parathyroid hormone (PTH). We have shown that extracts of eel CS contain proteins related to these PTH-related peptides (PTHrp) and, furthermore, that reptiles, amphibians, fish and Agnatha have DNA fragments homolo- gous to the chicken PTHrp gene. KEY WORDS: PTH, PTHrp, Stannius corpuscles, calcium regulation. Vertebrate tetrapods possess parathyroid glands secreting PTH, which controls the serum calcium concentration. In fish, these glands do not exist. However, holostean and teleostean fishes possess Stannius cor- puscles (CS), which produce factors that control serum calcium (FON- TAINr., 1964) by acting at the gills (MILE'R et al., 1979). A number of data suggest that these factors are functionnally and immunologically related to PTH: in the eel (Anguilla anguilla) removal of CS induces an increase in serum calcium concentration which is counteracted by injection of synthetic human PTH 1-34 (MILET et al., 1980). Further- more, antibodies raised

Journal

Netherlands Journal of Zoology (in 2003 continued as Animal Biology) – Brill

Published: Jan 1, 1994

Keywords: PTH; PTHrp; calcium regulation; Stannius corpuscles

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