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Segregation Distortion in Unstructured and Structured Populations: Competition Between 'Sterile' t Haplotypes

Segregation Distortion in Unstructured and Structured Populations: Competition Between 'Sterile'... SEGREGATION DISTORTION IN UNSTRUCTURED AND STRUCTURED POPULATIONS: COMPETITION BETWEEN 'STERILE' t HAPLOTYPES by MICHIEL VAN BOVEN and FRANZ J. WEISSING (Department of Genetics, University of Groningen, RO. Box 14, 9750 AA Haren, The Netherlands) ABSTRACT By means of two simple models we investigate the competition between sex-specific segre- gation distorters in unstructured and structured populations. The models are motivated by the t complex of the house mouse. Some variants at this gene complex, the t haplotypes, distort Mendelian segregation in their favour in heterozygous males. The selective advantage at the gamete level is counterbalanced by strong negative fitness effects at the individual level. A large number of t haplotypes with varying degrees of segregation distortion has been found. In order to address this phenomenon we explicitly model the competition between two t haplotypes which induce male sterility when homozygous. Surprisingly, a distorter which is inferior at the gamete level and equivalent in every other respect to a more effi- cient distorter may well persist in a population. We argue that rare distorters are inherently favoured, and that, as a result, fitness considerations alone are not sufficient to predict the outcome of competition. Since 'sterile' t haplotypes are not http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Netherlands Journal of Zoology (in 2003 continued as Animal Biology) Brill

Segregation Distortion in Unstructured and Structured Populations: Competition Between 'Sterile' t Haplotypes

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Publisher
Brill
Copyright
© 1995 Koninklijke Brill NV, Leiden, The Netherlands
ISSN
0028-2960
eISSN
1568-542X
DOI
10.1163/156854295X00177
Publisher site
See Article on Publisher Site

Abstract

SEGREGATION DISTORTION IN UNSTRUCTURED AND STRUCTURED POPULATIONS: COMPETITION BETWEEN 'STERILE' t HAPLOTYPES by MICHIEL VAN BOVEN and FRANZ J. WEISSING (Department of Genetics, University of Groningen, RO. Box 14, 9750 AA Haren, The Netherlands) ABSTRACT By means of two simple models we investigate the competition between sex-specific segre- gation distorters in unstructured and structured populations. The models are motivated by the t complex of the house mouse. Some variants at this gene complex, the t haplotypes, distort Mendelian segregation in their favour in heterozygous males. The selective advantage at the gamete level is counterbalanced by strong negative fitness effects at the individual level. A large number of t haplotypes with varying degrees of segregation distortion has been found. In order to address this phenomenon we explicitly model the competition between two t haplotypes which induce male sterility when homozygous. Surprisingly, a distorter which is inferior at the gamete level and equivalent in every other respect to a more effi- cient distorter may well persist in a population. We argue that rare distorters are inherently favoured, and that, as a result, fitness considerations alone are not sufficient to predict the outcome of competition. Since 'sterile' t haplotypes are not

Journal

Netherlands Journal of Zoology (in 2003 continued as Animal Biology)Brill

Published: Jan 1, 1995

Keywords: metapopulation; mathematical model; meiotic drive; polymorphism; rareness advantage; segregation distortion; coexistence

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