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M. Hensgens, A. Goorhuis, O. Dekkers, E. Kuijper (2012)
Time interval of increased risk for Clostridium difficile infection after exposure to antibiotics.The Journal of antimicrobial chemotherapy, 67 3
N. Hise, Alex Bryant, Erin Hennessey, Andrew Crannage, J. Khoury, F. Manian (2016)
Efficacy of Oral Vancomycin in Preventing Recurrent Clostridium difficile Infection in Patients Treated With Systemic Antimicrobial Agents.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 63 5
Efficacy of Oral Vancomycin in Preventing Recurrent Clostridium difficile Infection in Patients Treated With Systemic Antimicrobial Agents TO THE EDITOR—We read with interest the recent study published by Van Hise and colleagues in which they evaluated the ef- ficacy of oral vancomycin prophylaxis (OVP) in preventing recurrent episodes of Clostridium difficile infection (CDI) in patients receiving systemic antimicro- bial therapy [1]. The authors performed a retrospective cohort study among pa- tients with a prior history of CDI and CORRESPONDENCE � CID 2016:63 (15 November) � 1391 subsequent antibiotic exposure and con- would result in overestimating the effect cluded that the receipt of OVP was asso- of OVP. ciated with a significantly lower risk of Last, the testing for recurrent C. diffi- C. difficile recurrence. These findings are cile was not blinded to the use of prophy- both important and timely given the bur- laxis. It is possible that differential testing den of CDI on our hospital systems and in the 2 arms was responsible for the dif- community. Indeed, the Centers for Dis- ferences. For example, testing in cases ease Control and Prevention (CDC) with noninfectious diarrhea may have states that prevention of CDI is a national been deferred
Clinical Infectious Diseases – Oxford University Press
Published: Nov 15, 2016
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