PLoS Biology Volume 9 Issue 12, Page 2

Journal Article

Gut Microbiota Is a Key Modulator of Insulin Resistance in TLR 2 Knockout Mice

Andréa M., Caricilli; Paty K., Picardi; Lélia L., de Abreu; Mirian, Ueno; Patrícia O., Prada;

2011 PLoS Biology

doi:10.1371/journal.pbio.1001212 pmid:22162948

Environmental factors and host genetics interact to control the gut microbiota, which may have a role in the development of obesity and insulin resistance. TLR2-deficient mice, under germ-free conditions, are protected from diet-induced insulin resistance. It is possible that the presence of gut...

Open Access

Journal Article

Jamb and Jamc Are Essential for Vertebrate Myocyte Fusion

Gareth T., Powell; Gavin J., Wright

2011 PLoS Biology

doi:10.1371/journal.pbio.1001216 pmid:22180726

Cellular fusion is required in the development of several tissues, including skeletal muscle. In vertebrates, this process is poorly understood and lacks an in vivo-validated cell surface heterophilic receptor pair that is necessary for fusion. Identification of essential cell surface...

Open Access

Journal Article

Why ONE Is More Than 5

Catriona J., MacCallum

2011 PLoS Biology

doi:10.1371/journal.pbio.1001235

Open Access

Journal Article

Structural Basis of Response Regulator Inhibition by a Bacterial Anti-Activator Protein

Melinda D., Baker; Matthew B., Neiditch

2011 PLoS Biology

doi:10.1371/journal.pbio.1001226 pmid:22215984

The complex interplay between the response regulator ComA, the anti-activator RapF, and the signaling peptide PhrF controls competence development in Bacillus subtilis . More specifically, ComA drives the expression of genetic competence genes, while RapF inhibits the interaction of ComA with its...

Open Access

Journal Article

Coupled Motions Direct Electrons along Human Microsomal P450 Chains

Christopher R., Pudney; Basile, Khara; Linus O., Johannissen; Nigel S., Scrutton

2011 PLoS Biology

doi:10.1371/journal.pbio.1001222 pmid:22205878

Protein domain motion is often implicated in biological electron transfer, but the general significance of motion is not clear. Motion has been implicated in the transfer of electrons from human cytochrome P450 reductase (CPR) to all microsomal cytochrome P450s (CYPs). Our hypothesis is that...

Open Access

Journal Article

eBird: Engaging Birders in Science and Conservation

Chris, Wood; Brian, Sullivan; Marshall, Iliff; Daniel, Fink; Steve, Kelling

2011 PLoS Biology

doi:10.1371/journal.pbio.1001220 pmid:22205876

Open Access

Journal Article

How the Brain Homes in on Valuable Objects

Janelle, Weaver

2011 PLoS Biology

doi:10.1371/journal.pbio.1001228 pmid:22215985

Open Access

Journal Article

Mechanotransduction In Vivo by Repeated Talin Stretch-Relaxation Events Depends upon Vinculin

Felix, Margadant; Li Li, Chew; Xian, Hu; Hanry, Yu; Neil, Bate;

2011 PLoS Biology

doi:10.1371/journal.pbio.1001223 pmid:22205879

Mechanotransduction is a critical function for cells, in terms of cell viability, shaping of tissues, and cellular behavior. In vitro, cellular level forces can stretch adhesion proteins that link extracellular matrix to the actin cytoskeleton exposing hidden binding sites. However, there is no...

Open Access

Journal Article

The Case of the Fickle Fingers: How the PRDM9 Zinc Finger Protein Specifies Meiotic Recombination Hotspots in Humans

Laure, Ségurel; Ellen Miranda, Leffler; Molly, Przeworski

2011 PLoS Biology

doi:10.1371/journal.pbio.1001211 pmid:22162947

During mammalian meiosis, double-strand breaks are deliberately made throughout the genome and then repaired, leading to the exchange of genetic material between copies of chromosomes. How the locations of breaks are specified was largely unknown until a fortuitous confluence of statistical...

Open Access

Journal Article

Specific Contributions of Ventromedial, Anterior Cingulate, and Lateral Prefrontal Cortex for Attentional Selection and Stimulus Valuation

Daniel, Kaping; Martin, Vinck; R. Matthew, Hutchison; Stefan, Everling; Thilo, Womelsdorf

2011 PLoS Biology

doi:10.1371/journal.pbio.1001224 pmid:22215982

Attentional control ensures that neuronal processes prioritize the most relevant stimulus in a given environment. Controlling which stimulus is attended thus originates from neurons encoding the relevance of stimuli, i.e. their expected value, in hand with neurons encoding contextual information...

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PLoS Biology Volume 9 Issue 12

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