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Immunopharmacology and Immunotoxicology Volume 14 Issue 4

Subject Areas: Immunology; ; ; ; ; ;
Publisher: Taylor & Francis - Taylor & Francis
ISSN: 1532-2513
SJR: 53

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Journal Article

Significant Anti-HIV Activity of New Modified Poly Anionic Polymers in vitro

Buckheit, Robert W.; White, E. Lucile; Shannon, William M.; Guerrero, A.; Pivel, J.P.; Carrasco, L.; Leal, J.A.; Chirigos, Michael A.

1992 Immunopharmacology & Immunotoxicology

doi:10.3109/08923979209009229 pmid:1294618

AbstractThe anti-HIV activities of two new polyanionic polymers (AM 242 and AM 612) were investigated in cell culture-based and biochemical antiviral assays. These compounds inhibited the reverse transcriptases from HIV-1 and HIV-2, using enzyme purified from virions and either a ribosomal RNA or...
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Journal Article

Effect of Metals on Interleukin-6 (IL-6) Mitogenic Stimulation of Murine Hybridoma Cells

Orupabo, I.; Hay, A.; Evans, S.W.

1992 Immunopharmacology & Immunotoxicology

doi:10.3109/08923979209009230 pmid:1294619

AbstractThe effect of several divalent metal cations (Co, Cu, Zn, Hg and Pb) on the proliferative response of B9 hybridoma cells to IL-6 has been investigated. At concentrations which are not cytotoxic all the metals inhibited proliferation. The inhibition by Cd and Pb was dependent on both time...
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Journal Article

Pidotimod Stimulates Natural Killer Cell Activity and Inhibits Thymocyte Cell Death

Migliorati, Graziella; D'adamio, Luciano; Coppi, Germano; Nicoletti, Ildo; Riccardi, Carlo

1992 Immunopharmacology & Immunotoxicology

doi:10.3109/08923979209009231 pmid:1294620

AbstractExperiments were performed to analyze the possible effect of the immunomodulating agent Pidotimod (3-L-pyroglutamyl-L-thiazolidine-4-carboxylic acid) on mouse Natural Killer (NK) cell activity and glucocorticoid hormone(GCH)-induced thymocyte apoptosis. The results indicate that in vivo...
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Journal Article

On the Physiological Significance of Tumor Necrosis Factor-α in the Human Amniotic Fluid

Covelli, V.; Jaccarino, M.; Massari, F.; Jaccarino, S.; Munno, I.; Marinaro, M.; Gesario, A.; Pellegrino, N.M.; Jirillo, E.

1992 Immunopharmacology & Immunotoxicology

doi:10.3109/08923979209009232 pmid:1284129
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Journal Article

A Short Incubation with PGE2 Affects the Proliferative Response of T Lymphocytes to PWM

Santarpia, Gerardo; Valenti, Andrea; Loteta, Letterio; Sofo, Vincenza; Sottile, Antonino; Serrao, Nicola; Salmeri, Francesca M.; Teti, Diana

1992 Immunopharmacology & Immunotoxicology

doi:10.3109/08923979209009233 pmid:1294621

AbstractIn this study we have investigated the role of PGE2 in the activation of human T lymphocytes by PWM. A preincubation of these cells with molar concentrations of the prostaglandin ranging from 10-9 M to 10-4 M is able to reduce the expression of IL-2R and CD71 on T lymphocyte membrane...
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Journal Article

Antimicrobial Agents Induce Monocytes to Release IL-1α, IL-6, and Tnf and Induce Lymphocytes to Release IL-4 and TNFτ

Tufano, M.A.; l'Ero, G. Cipollaro de; Ianniello, R.; Baroni, A.; Galdlero, F.

1992 Immunopharmacology & Immunotoxicology

doi:10.3109/08923979209009234 pmid:1294622

AbstractEvaluation was carried out on the action of different antibiotics on the release of cytokines. Experiments were done in vitro on monocytes and on human lymphocytes. Results show that the majority of the antibiotics tested are able to induce the release of one or more cytokines from their...
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Journal Article

Regulation of Murine T-Lymphocyte Function by Spleen Cell-Derived and Exogenous Serotonin

Kut, Joseph L.; Young, M. Rita I.; Crayton, John W.; Wright, Mark A.; Young, Mel E.

1992 Immunopharmacology & Immunotoxicology

doi:10.3109/08923979209009235 pmid:1294623

AbstractThe modulatory effects of serotonin on T-cell activity were investigated. T-cell blastogenesis of normal spleen cells was slightly stimulated by the addition of low doses (1 and 10 ng/ml) of the inducer of serotonin release, fenfluramine. In contrast to the stimulatory effects of low...
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Journal Article

β-Lactam Antibiotic Modulation of Murine Neutrophil Cytokinesis

Kenny, M.T.; Balistreri, F.J.; Torney, H.L.

1992 Immunopharmacology & Immunotoxicology

doi:10.3109/08923979209009236 pmid:1294624

AbstractFourteen cephalosporins, 11 penicillins and 1 monobactam were evaluated for their in vitro modulation of murine neutrophil cytokinesis. As a result, the β-lactam antibiotics were placed into 6 groups based on their effect on random (R) and FMLP-directed (D) migration [Group 1 (no effect)...
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Journal Article

Effect of Zinc on Immune Functions and Host Resistance Against Infection and Tumor Challenge

Singh, K.P.; Zaidi, S.I.A.; Raisuddin, S.; Saxena, A.K.; Murthy, R.C.; Ray, P.K.

1992 Immunopharmacology & Immunotoxicology

doi:10.3109/08923979209009237 pmid:1338205

AbstractThe effect of zinc treatment on immune function and resistance against infection and tumor challenge was studied in mice. Swiss albino mice were treated with zinc acetate (3 mg/kg body weight) in one or two intraperitoneal injections. Various immune function assays were performed in...
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Journal Article

Preventive Effect of A Synthetic Immunomodulator, 2-Carboxyethylgermantum Sesquioxide, on the Generation of Suppressor Macrophages in Mice Immunized with Allogeneic Lymphocytes

Kobayashi, Hiroyuki; Aso, Hisashi; Ishida, Nakao; Maeda, Hiroshi; Schmitt, David A.; Pollard, Richard B.; Suzuki, Fujio

1992 Immunopharmacology & Immunotoxicology

doi:10.3109/08923979209009238 pmid:1294625

AbstractThe effect of 2-carboxyethylgermanium sesquioxide (Ge-132) on the generation of splenic suppressor macrophages (S-MØ) in C3H/He mice (H-2k) immunized with allogeneic spleen cells from C57B1/6 mice (H-2b) was investigated. We have previously demonstrated that S-MØ expressing I-J antigen,...

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